Mechanosynthesis of Eutectics of Anti‐Inflammatory Drug Ethenzamide – A Comparison with Analogous Cocrystals
نویسندگان
چکیده
Abstract Mechanochemical milling of ethenzamide (ETZ), a nonsteroidal anti‐inflammatory drug, with substituted aromatic carboxylic acids as well anti‐tuberculosis drug pyrazinamide (PZA) resulted in the formation eutectics. Although large number cocrystals polymorphic are reported for ETZ, first time we have synthesized six eutectics including an instance drug‐drug eutectic system. Supramolecular synthon energy calculations validate mixtures over coformers considered our study.
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ژورنال
عنوان ژورنال: Chemistry methods
سال: 2021
ISSN: ['2628-9725']
DOI: https://doi.org/10.1002/cmtd.202100016